Timetables uncovered by Memory Lane reader David Brown show that a stagecoach service was operating between the two cities as late as 1928.
You could take the stagecoach from Oxford to London, then catch a train back to Oxford, or vice versa.
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Oxford Mail
Before we had the Oxford Tube/X90, we had this. It only cost £1, but on the other hand it took eight hours…
This link was originally posted to /r/oxford. See more things from Dan's Reddit account.
The original link was: http://www.oxfordmail.co.uk/news/community/memorylane/10962771.Recalling_the_last_days_of_horse_drawn_route_to_London/